ACE inhibitors prevent an enzyme in the body from making angiotensin 2, a substance that narrows blood vessels . This narrowing can cause high blood pressure and forces the heart to work harder. Angiotensin 2 also releases hormones that raise blood pressure.
ACE inhibitors are drugs that lower blood pressure by dilating blood vessels. They work by preventing the conversion of angiotensin I to angiotensin II. |
Mechanism of action These drugs inhibit competitively the activity of ACE (also termed kininase II) to prevent formation of the active octapeptide, angiotensin ... |
ACE inhibitors block the breakdown of bradykinin, causing levels of this protein to rise and blood vessels to widen (vasodilation). Increased bradykinin levels ... |
Angiotensin-Converting Enzyme Inhibitors | Circulation www.ahajournals.org › doi › 01.cir.97.14.1411
14 апр. 1998 г. · ACE inhibitors promote salt excretion by augmenting renal blood flow and by reducing the production of aldosterone and antidiuretic hormone. |
This concept of tissue ACE has improved our understanding of the mechanisms of action of ACE inhibition in the treatment of hypertension and heart failure. |
The mechanism of action for ACE inhibitors is through decreasing angiotensin II generation. ACE inhibitors not only treat hypertension but also have ... |
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