MECHANISM OF ACTION. Aminoglycosides inhibit protein synthesis by binding, with high affinity, to the A-site on the 16S ribosomal RNA of the 30S ribosome (Kotra et al. 2000). Although aminoglycoside class members have a different specificity for different regions on the A-site, all alter its conformation.
Aminoglycosides have concentration-dependent bactericidal activity. These antibiotics bind to the 30S ribosome, thereby inhibiting bacterial protein synthesis. |
Aminoglycosides are broad spectrum antibiotics with potent activity mediated through inhibition of protein synthesis. This class of antibiotic was a fundamental ... |
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis |
The mechanism of action of aminoglycosides depends on the inhibition of polypeptide synthesis. In fact, some of them such as Streptomycin, Sisomicin and ... |
12 дек. 2022 г. · bovis/S. equinus complex'.) The aminoglycosides primarily act by binding to the aminoacyl site of 16S ribosomal RNA within the 30S ribosomal ... |
The general mechanism of action of aminoglycosides is inhibition of protein synthesis by promotion of mistranslation and elimination of proofreading [11]. |
Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections (28). |
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