AMP-activated protein kinase (AMPK) is a major cellular regulator of lipid and glucose metabolism. Here we report that metformin activates AMPK in ...

5′ AMP-activated protein kinase activation has been found to be a common link between the many activities of metformin (Agius et al., 2020; Lu et al., 2021). Abstract · Introduction · 5′AMP-activated protein...

1 авг. 2002 г. · Metformin, a drug widely used to treat type 2 diabetes, was recently shown to activate the AMP-activated protein kinase (AMPK) in intact ... RESEARCH DESIGN AND... · RESULTS · DISCUSSION

We find that low concentrations of metformin promote the formation of the AMPK αβγ complex, resulting in an increase in net phosphorylation of the AMPK α ...

23 февр. 2022 г. · Metformin binds PEN2 and initiates a signalling route that intersects, through ATP6AP1, the lysosomal glucose-sensing pathway for AMPK activation.

23 сент. 2011 г. · The glucose-lowering drug metformin has been shown to activate hepatic AMP-activated protein kinase (AMPK), a master kinase regulating ...

There is widespread consensus that the activation of AMPK by metformin first reported 20 years ago occurs at therapeutic doses of the drug [3,4] and is involved ...

Recent studies demonstrate that metformin activates AMPK in vitro and in vivo (11, 12). Activation of AMPK by metformin is found to be required for the decrease ...

3 авг. 2017 г. · Metformin has been shown to act via both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms; by inhibition of mitochondrial ...