Several classes of antibiotics have been developed to target gram-negative bacteria, including aminopenicillins, ureidopenicillins, cephalosporins, beta-lactam-betalactamase inhibitor combinations (such as piperacillin-tazobactam), folate antagonists, quinolones, and carbapenems.
New treatment options, such as ceftazidime/avibactam, meropenem/vaborbactam, ceftolozane/tazobactam, plazomicin, and eravacycline have become available. |
A high clinical success rate of 83.2% has been recorded using ceftolozane-tazobactam in the treatment of various types of Pseudomonas aeruginosa infections, of ... |
29 мая 2024 г. · Here we report the design and discovery of lolamicin, a Gram-negative-specific antibiotic targeting the lipoprotein transport system. |
Aerobic Gram Negative Bacteria: COCCI, Neisseria, Moraxella, RODS/BACILLI -> aminoglycosides are good agents (gentamicin, tobramycin, amikacin, streptomycin) |
Fluoroquinolones (FQs) remain the most commonly used oral antibiotic for GNBSI. Oral trimethoprim/sulfamethoxazole and β-lactams appear equally as efficacious ... |
1 июл. 2012 г. · For infections with Gram-negative bacteria, antimicrobial synergy has traditionally been seen with β-lactam–aminoglycoside combinations. The ... |
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