Several classes of antibiotics have been developed to target gram-negative bacteria, including aminopenicillins, ureidopenicillins, cephalosporins, beta-lactam-betalactamase inhibitor combinations (such as piperacillin-tazobactam), folate antagonists, quinolones, and carbapenems.
New treatment options, such as ceftazidime/avibactam, meropenem/vaborbactam, ceftolozane/tazobactam, plazomicin, and eravacycline have become available. |
Minocycline combined with colistin is effective for treating minocycline-resistant A. baumannii infections and colistin/rifampin is the most effective treatment ... |
Aerobic Gram Negative Bacteria: COCCI, Neisseria, Moraxella, RODS/BACILLI -> aminoglycosides are good agents (gentamicin, tobramycin, amikacin, streptomycin) |
Fluoroquinolones (FQs) remain the most commonly used oral antibiotic for GNBSI. Oral trimethoprim/sulfamethoxazole and β-lactams appear equally as efficacious ... |
29 мая 2024 г. · Here we report the design and discovery of lolamicin, a Gram-negative-specific antibiotic targeting the lipoprotein transport system. |
Imipenem-relebactam could offer an important new treatment option as part of an empirical or targeted therapy for HAP or VAP due to MDR Gram-negative bacteria. ... |
4 июл. 2023 г. · baumannii involves a combination of antibiotics, including colistin, aminoglycosides, tigecycline, and ampicillin–sulbactam, depending on the ... |
For MDR GNRs that are resistant to carbapenems, treatment options included toxic antibiotics such as polymyxins and aminoglycosides or antibiotics with ... |
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