Fluoroquinolones (FQs) are effective for oral step-down therapy for gram-negative bloodstream infections but are associated with unfavorable toxic effects. Robust data are lacking for trimethoprim-sulfamethoxazole (TMP-SMX) and high-bioavailability β-lactams (HBBLs).
16 февр. 2024 г.
To date, small trials have supported the use of specific classes of antibiotics, primarily fluoroquinolones (FQs), in the treatment of Gram-negative bloodstream ... |
26 янв. 2023 г. · Of the patients transitioned to oral therapy, most (84%) received a “highly bioavailable” antibiotic (fluoroquinolone or trimethoprim- ... |
18 дек. 2023 г. · Although oral amoxicillin is widely used against enterococcal and streptococcal bacteremia, as well as in amoxicillin-sensitive Enterobacterales ... |
2 янв. 2024 г. · In this study, fluoroquinolones were the preferred agent. Although oral transition to highly orally bioavailable agents such as fluoroquinolones ... |
17 окт. 2023 г. · Post-randomization, oral cephalosporins, and β-lactam/β-lactamase inhibitor combinations were the most frequent agents used in the Oral Group, ... |
29 сент. 2021 г. · Oral step-down therapy with a fluoroquinolone or TMP/SMX is recognized as a viable option in patients with Enterobacterales BSI who meet inclusion criteria. |
19 июл. 2022 г. · High-bioavailability oral antibiotics such as fluoroquinolones or trimethoprim-sulfamethoxazole have been utilised for Gram-negative bacteraemia ... |
Oral antibiotic stepdown therapy is a safe, convenient, less costly alternative to outpatient intravenous antibiotics for gram-negative bloodstream infections ... Abstract · METHODS · RESULTS · DISCUSSION |
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