It is an integrase inhibitor with a carbamoyl pyridone structure similar to that of dolutegravir. In December 2021, the U.S. Food and Drug Administration ...

During 3' processing, one magnesium ion activates a water molecule for nucleophilic attack, while the second metal ion destabilizes the scissile phosphodiester ...

Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase 1A1 and is unlikely to be impacted by the cytochrome P450 metabolic pathway ...

Mechanism of action. Cabotegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral ...

25 апр. 2022 г. · Cabotegravir acts as an integrase strand transfer inhibitor. It blocks HIV integrase by attaching to the active integrase site and inhibiting ...

13 нояб. 2024 г. · Cabotegravir's mechanism of action involves blocking an enzyme called HIV integrase that is essential for HIV replication. Cabotegravir belongs ...

17 июл. 2024 г. · Its mechanism of action involves the inhibition of HIV integrase, an enzyme that is essential for the viral replication cycle. This integrase ...

15 апр. 2022 г. · All medications in the INSTI class bind to the integrase active site, thereby blocking viral DNA integration and subsequent HIV replication.

6 сент. 2024 г. · Cabotegravir injection exhibits limited absorption kinetics (flip-flop model). Its slow absorption from the gluteal muscle to the systemic ...