19 июл. 2022 г. · Exploration of metformin also showed that it could induce osteogenic effects crucial for bone formation [14]. The Diabetes Prevention Program ...

This meta-analysis indicated that metformin had no significant effect on BMD. Metformin decreased some bone turnover markers.

Research conclusions. A high dosage of metformin can help to improve osteoporosis as well as control blood glucose in elderly male patients with type 2 diabetes ...

Metformin treatment was associated with a higher T-score and a lower odds ratio of osteopenia and osteoporosis, especially in the female population, ...

27 окт. 2023 г. · We can conclude that the use of metformin is a protective factor for osteoporosis and that the use of metformin has a causal relationship with osteoporosis.

26 нояб. 2019 г. · Metformin has a certain effect on microangiopathy and anti-inflammation, which can induce osteoporosis, activate the activity of osteoclasts, and inhibit ...

11 янв. 2023 г. · Several studies demonstrated that metformin treatment was associated with significant low bone fracture risks in patients with diabetes (65, 66) ...

Metformin oral administration has osteogenic effects both in vivo and in vitro and it improves bone healing in non-diabetic animals by increasing osteoblast ...

27 мар. 2024 г. · This study indicated that metformin treatment is significantly associated with a reduction in the risk of OP, fracture and higher LS-BMD, FN-BMD, and eBMD.

In contrast, metformin and sulfonylureas do not appear to have a negative effect on bone health and may, in fact, protect against fragility fracture.