There are four CFTR modulators for people with certain CFTR mutations: Trikafta® (elexacaftor/tezacaftor/ivacaftor); Symdeko® (tezacaftor/ivacaftor); Orkambi® ( ...

CFTR modulators for the treatment of cystic fibrosis are a growing area that is quickly changing. Ivacaftor, the first CFTR potentiator to receive FDA approval, ...

Defects in a single gene lead to the defective proteins that cause cystic fibrosis, making the disease an ideal candidate for mutation-targeted therapy.

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are a class of drugs that act by improving production, intracellular processing, and/or ...

Highlights · CFTR Modulators target the underlying protein defects in CF. · Elexacaftor/tezacaftor/ivacaftor is highly effective and widely applicable.

There are two main types of CFTR modulators: potentiators and correctors. Potentiators are CFTR modulators that hold the gate to the CFTR channel open so ...

CFTR modulators work differently to other medications for CF. They work by correcting the malfunctioning protein that causes CF.

9 сент. 2023 г. · CFTR modulators are a class of orally administered drugs developed to affect dysfunctional CFTR proteins. All currently available CFTR ...

Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration | European Respiratory Society.

Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies work to correct the malfunctioning protein made by the CFTR gene.