Absorption is at least 50% based on urinary excretion of clopidogrel-related metabolites.

In the liver, approximately 15% of absorbed clopidogrel is metabolized by the cytochrome P450 (CYP) system to generate its active metabolite via a 2-step ...

The urinary excretion of SR26334 was low-2.2 to 2.4% of the dose administered-and Cl(r-2-24) remained virtually constant at all four doses. Median T(max)(0.8- ...

Following oral administration, clopidogrel is rapidly absorbed. Due to its extensive metabolism, clopidogrel is not detected in human plasma. Clopidogrel is ...

Absorption is at least 50%, based on urinary excretion of clopidogrel metabolites. Effect of Food: The effect of food on the bioavailability of the parent ...

Following an oral dose of 14C-labeled clopidogrel in humans, approximately 50% of total radioactivity was excreted in urine and approximately 46% in feces over ...

The elimination half-life of the main circulating metabolite is 8 hours. It is extensively metabolized by the liver and requires no renal dose adjustment. An ...

After single and repeated oral doses of 75 mg per day, clopidogrel is rapidly absorbed. Absorption is at least 50%, based on urinary excretion of clopidogrel ... Dosage · Side Effects · Drug Interactions · Precautions

The urinary excretion of SR26334 represented about 2% of the administered dose. This indicates that most of clopidogrel and SR26334 is excreted as metabolites.