8 мар. 2012 г. · The effectiveness of clopidogrel depends on its conversion to an active metabolite, which is accomplished by the cytochrome P450 2C19 (CYP2C19) enzyme. Drug: Clopidogrel · Gene: CYP2C19 · Therapeutic... |
Clopidogrel metabolism can also be influenced by genetic variants in other proteins, such as the ATP-Binding Cassette Subfamily B Member 1 (ABCB1), Paraoxonase- ... |
Association with CYP2C19 polymorphisms and Clopidogrel in ... bmcneurol.biomedcentral.com › articles
9 мар. 2021 г. · Clopidogrel is a prodrug that needs to be metabolized by the liver cytochrome P450 (CYP450) enzymes to be converted into an active drug. CYP2C19 ... |
14 февр. 2019 г. · CYP2C19 rapid and ultrarapid metabolizers treated with clopidogrel exhibit increased active metabolite formation and inhibition of platelet ... |
The major metabolic pathway of clopidogrel is conversion to carboxylic acid by an esterase (CES1), forming clopidogrelic acid (SR26334) that is inactive. There ... |
The drug label suggests that a different platelet P2Y12 inhibitor be used in patients identified as CYP2C19 poor metabolizers. The FDA label change does not ... |
9 нояб. 2021 г. · Variations in CYP2C19 are most often associated with reduced enzyme activity and decreased metabolism of clopidogrel, leading to a low level of ... |
Several data resources suggest that polymorphic expression of CYP2C19 plays an essential role in the metabolism and efficacy of many drugs. The distribution of ... |
| Novbeti > |
| Axtarisha Qayit Anarim.Az Anarim.Az Sayt Rehberliyi ile Elaqe Saytdan Istifade Qaydalari Anarim.Az 2004-2023 |