Aspirin inhibits platelet cyclooxygenase by irreversible acetylation, thereby preventing the formation of thromboxane A2 which is a powerful stimulant of platelet aggregation [4]. Clopidogrel, a thienopyridine, acts by inhibiting adenosine receptors, which inhibits the early step of platelet activation [5].
20 апр. 2023 г. · Aspirin causes inhibition of protective COX enzymes while clopidogrel results in suppression of platelet-derived growth factor, reduced ... |
Aspirin and clopidogrel exert their antiplatelet effects by inhibiting thromboxane A2 production and adenosine diphosphate–induced platelet aggregation pathways ... |
Aspirin works by irreversibly acetylating the cyclooxygenase (COX)-1 enzyme, thus suppressing thromboxane A2.18 Thromboxane A2 serves as a potent agonist of ... |
In this prospective clinical ex vivo platelet study, clopidogrel was more effective than aspirin in inhibiting ADP-mediated platelet aggregation and activation. |
28 сент. 2018 г. · Clopidogrel is another guideline‐recommended antiplatelet agent and has been shown to be superior to aspirin in preventing composite vascular ... |
Among patients with an ischaemic stroke while taking aspirin, clopidogrel initiation was associated with fewer recurrent vascular events than aspirin ... |
Clopidogrel is an alternative to aspirin in allergic or intolerant patients, and in combination with aspirin it is more effective than aspirin alone in ... |
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