Cystic fibrosis occurs when the cystic fibrosis transmembrane conductance regulator (CFTR) protein is either not made correctly, or not made at all.

Mutations in the CFTR gene lead to defective CFTR expression or function. This triggers abnormalities in ion transport and thus in water absorption which ...

The key mechanisms in the development of CF lung disease are shown in Figure 1. In normal airway epithelia, CFTR-mediated Cl- secretion and ENaC mediated Na+ ...

Cystic fibrosis is caused by mutations in the gene that produces the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This protein is ...

Cystic fibrosis is an autosomal recessive disease caused by a mutation in the CFTR gene resulting in multisystem dysfunction.

Thus, inflammatory cells and micro-organisms sustain IL-8 levels in CF airways and perpetuate a positive feedback loop that amplifies the inflammatory response.

3 окт. 2024 г. · Cystic fibrosis is an autosomal recessive disease caused by defects in the CFTR gene, which encodes for a protein that functions as a chloride ...

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Опубликовано: 19 апр. 2018 г.

Cystic fibrosis is caused by mutations in the CFTR gene, which encodes a chloride channel located on the surface of certain epithelial cells.