The partition coefficient is determined by the shake flask method using two immiscible solvents , the most common hydrophilic solvent is water or phosphate buffer of pH 7.4, and for oil phase is octanol.
9 янв. 2024 г. · In experimental settings, the partition coefficient is determined by measuring the concentrations of the solute in each phase. The values ... |
25 февр. 2020 г. · Distribution coefficients for all analytes were derived from the difference in the blank corrected peak areas of the toxin in both the reference ... |
Partition coefficients are difficult to measure in living systems, and are usually determined in vitro using 1-octanol (n-octanol) as the lipid phase and pH 7. ... |
A partition coefficient is defined as the ratio of the compound concentration in two specific phases under constant environmental conditions. From: Encyclopedia ... |
In order to determine the partitioning coefficient, water, 1-octanol, and the test chemical are equilibrated with each other at constant temperature. Then the ... |
The ratio of the concentration of the solute in the two liquids is known as distribution coefficient or partition coefficient. Partition Coefficient = [ ... |
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