Class IV antiarrhythmic drugs block slow cardiac calcium channels, inhibit extracellular calcium influx, slow the conduction of the atrioventricular node, and ...

Class IV, nondihydropyridine calcium channel blockers: These drugs block calcium channels in heart muscle. This can decrease heart rate and contractions.

All antiarrhythmic drugs directly or indirectly alter membrane ion conductances, which alters the physical characteristics of cardiac action potentials. For ...

Combinations of these drugs reduce cardiac contractility and increase the risk of bradycardia, intracardiac conduction disturbances, and proarrhythmia. Co- ... Decisions to initiate... · Classification of antiarrhythmic...

6 февр. 2021 г. · Each class has distinct effects on the shape of the cardiac action potential: Effects of antiarrhythmic drugs on the cardiac action potential.

Antiarrhythmic drugs exert their effects on cardiac electrical impulse formation and propagation via their interaction with ionic channels or with membrane ...

17 янв. 2012 г. · The majority of available antiarrhythmic drugs exert predominant effects on cardiac sodium or potassium currents. The sodium channel blocking ...

Congestive heart failure and AV block are the major severe cardiac side effects. After large doses, severe bradycardia or asystole may occur. Sudden withdrawal ...

Antiarrhythmic drugs suppress these ectopic beats primarily by decreasing the rate of spontaneous diastolic depolarization (phase 4 slope) of the aberrant foci.

22 окт. 2018 г. · The only currently clinically adopted Class 0 agent, ivabradine, is used to reduce heart rates in situations of inappropriate sinus tachycardia ...