Aminoglycoside entry into bacterial cells is comprised of three distinct stages, the first of which increases permeability of the bacterial membrane, whereas ...

25 сент. 2023 г. · Ototoxicity from aminoglycosides is permanent and is a consequence of its action on the inner ear cells via multiple mechanisms. Both ...

13 янв. 2022 г. · The present review summarizes recent publications devoted to aminoglycosides that study the main types of resistance to antibiotics of this class.

Plazomicin (formerly ACHN-490) is a next-generation aminoglycoside that was synthetically derived from sisomicin by appending a hydroxy-aminobutyric acid ...

Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis ...

The first generation of aminoglycosides were isolated from bacterial species Streptomyces and Micromonospora. Streptomycin, isolated in 1944 from ...

2 июн. 2021 г. · Plazomicin is currently the only next-generation aminoglycoside approved for clinical use that has the potential of evading the effects of ...

Aminoglycosides have concentration-dependent bactericidal activity. These antibiotics bind to the 30S ribosome, thereby inhibiting bacterial protein synthesis.

Production of AMEs is the most common, occurring in both staphylococci and Gram-negative bacteria. Enzymes that modify specific drugs either by N-acetylation, O ...

The final energy-dependent stage of uptake (energy-dependent phase II) results in the rapid movement of aminoglycoside molecules into the cytoplasm (Fig. 1C) ( ...