10 дек. 2014 г. · Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci.

Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci.

22 окт. 2024 г. · Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic ...

10 дек. 2014 г. · Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic ...

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. ... Expresses the MS2-P65-HSF1 activator helper complex with a 2A GFP. 3rd ...

Structural-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci is described and the ...

We used these engineered Cas9 activation complexes to investigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to ...

Genome-scale transcriptional activation by an engineered. CRISPR-Cas9 complex ... The Kolmogorov-Smirnov method was used to score genes. Gene. NES. Gene rank.

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. · High-throughput functional genomics using CRISPR–Cas9 · Genome-Scale CRISPR- ...

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. · High-throughput functional genomics using CRISPR–Cas9 · Genome-Scale CRISPR- ...