Hedgehog pathway inhibitors, also sometimes called hedgehog inhibitors, are small molecules that inhibit the activity of a component of the Hedgehog signaling ... Overview of the Hedgehog... · Mechanism of action

In this review, we briefly overview canonical and non-canonical Hh pathways and their inhibitors as targeted cancer therapy.

12 мар. 2021 г. · The systemic treatments of BCC act to inhibit the HP and are called hedgehog pathway inhibitors. The first one being vismodegib and the second ...

Hedgehog pathway inhibitors may be used to treat basal cell carcinoma that has spread to other parts of the body.

14 июн. 2022 г. · Hh pathway inhibitors vismodegib and sonidegib are currently indicated for BCC, in adults with advanced or recurred tumor following surgery or radiation ...

20 апр. 2016 г. · Hedgehog pathway inhibitors are an effective, well-tolerated therapy for laBCC and mBCC and have great potential to improve quality of life for ...

Hedgehog pathway inhibitors are the potential therapeutic approach for the treatment of basal cell carcinoma.

Drug, Drug Description. Vismodegib, A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma.

7 июн. 2012 г. · Vismodegib is a new orally administered hedgehog-pathway inhibitor that produces objective responses in locally advanced and metastatic basal-cell carcinomas.

15 окт. 2012 г. · Here, we summarize the effectiveness of Hedgehog pathway inhibitors and highlight promising areas for the development of next generation drug antagonists.