20 мар. 2018 г. · Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. |
18 авг. 2023 г. · HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. |
Deregulation of the Hh signaling pathway is associated with developmental anomalies and cancer, including Gorlin syndrome, and sporadic cancers. |
Hh signaling has been implicated in regulation of differentiation, proliferation, tissue polarity, stem cell population and carcinogenesis. |
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