High oxygen affinity hemoglobins are responsible for rare and heterogeneous autosomic dominant genetic diseases. They cause pure erythrocytosis.

14 янв. 2024 г. · High-oxygen-affinity hemoglobins are caused by rare β globin mutations; they are inherited in a dominant autosomal manner and may have variable ...

28 янв. 2019 г. · Altered oxygen affinity variant Hbs are caused by rare inherited globin gene mutations. The first step in identifying a variant Hb is awareness of common ... PATHOPHYSIOLOGY OF... · DIAGNOSTIC TESTS

11 окт. 2024 г. · Variants that increase the affinity of hemoglobin for oxygen cause isolated erythrocytosis. Variants that decrease the affinity of hemoglobin ...

30 апр. 2010 г. · In haemoglobinopathies that show high oxygen affinity, the lower release of oxygen leads to tissue hypoxia that prompts erythropoietin output at ...

10 авг. 2023 г. · A high oxygen affinity results in lower oxygen delivery in peripheral tissues, including the renal oxygen-sensing mechanism. This triggers a ...

A high oxygen affinity variant has to be suspected when the hemoglobin level is at the upper limits of the normal in females or individuals with a mild iron ...

9 янв. 2024 г. · In conclusion, high-oxygen-affinity hemoglobins are rare and inherited within a dominant autosomal manner, have various clinical presentations, ...

1 сент. 2009 г. · Approximately 100 hemoglobin variants with a high affinity for oxygen have been described that cause a decrease in the supply of oxygen to tissues.