Most cases of acromegaly exhibit high levels of serum insulin-like growth factor-1 (IGF-1). Acromegaly with normal IGF-1 levels is rare and difficult to ...

Elevated IGF-1 levels, alone, are sufficient to establish a diagnosis of acromegaly in the majority of clinically suspected cases.

24 авг. 2018 г. · The high level of IGF-1 in acromegaly is related to an increased risk of some cancers, particularly colon cancer and thyroid cancer. An ...

Serum IGF-1 levels were elevated in all patients with acromegaly, with a median SDS IGF-1 value of +9.52 (range: +2.34 to +39.2).

31 авг. 2023 г. · High IGF-1 levels stimulate excessive growth of skin, connective tissue, cartilage, bone, organs, and other tissues in the body; an exception is ...

IGF-I is the preferred diagnostic test since the presence of acromegaly in the context of a normal age-related serum IGF-I is exceedingly unusual. Furthermore, ...

Serum IGF-1 levels are typically normal or low in situations of GH resistance [1,15]. The mechanisms leading to GH resistance in the liver are summarised in Fig ...

IGF-1 levels are relatively stable and correlate to clinical acromegaly data and to increased plasma GH levels. No additional increase occurs in plasma IGF-1 ...

An oral glucose tolerance test should be performed if acromegaly is suspected despite normal levels of IGF-I and IGF-I binding protein 3.