Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Benoit St-Jacques ... |
11 сент. 2020 г. · Indian hedgehog (Ihh), is expressed in prehypertrophic and hypertrophic chondrocytes during endochondral ossification. |
Recent studies have shown that Ihh is a key molecule that regulates chondrocyte proliferation and differentiation during endochondral bone formation (14, 15, 17) ... |
Although bmp6 was expressed, ihh transcripts were not found in primordia of intramembranous bones, nor in cells lining the future articular surfaces. |
This review focuses on the role of one of these factors, Indian hedgehog, in skeletal development. Hedgehog (Hh) proteins are secreted morpho- gens that are ... |
29 сент. 2017 г. · It has been suggested that Ihh may induce adjacent perichondrial cells to differentiate into bone-forming osteoblasts (6). Ihh null mutant mice ... |
The second mechanism, called endochondral ossification, is used to form the bones of the axial and appendicular skeleton as well as some of the facial bones. |
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