4 февр. 2017 г. · In 95% of the cases it occurs sporadically but almost 50% of the childhood-onset cases have an identifiable genetic background, most commonly ...

This autosomal-dominant syndrome is caused by an inactivating mutation of the NF1 gene, located on chromosome 17q11.2. It encodes neurofibromin, a protein ...

6 февр. 2024 г. · People who have a rare genetic condition called multiple endocrine neoplasia, type 1 (MEN 1), have a higher risk of developing acromegaly.

Genetic causes of gigantism and acromegaly include multiple endocrine neoplasia type 1 and 4, McCune Albright syndrome, Carney complex, familial isolated ...

This is the most common genetic anomaly, being responsible for 99.3% of CNC patients with GH excess. A higher risk of developing acromegaly was observed in ...

Scientists aren't sure what causes pituitary tumors that cause acromegaly to develop, though they think certain genetic factors may play a role.

14 мая 2021 г. · In some patients, acromegaly may occur as part of certain genetic syndromes including multiple endocrine neoplasia type 1, familial isolated ...

Genetic counseling. This form of acromegaly is sporadic; a causal genetic mutation has not been identified. Management and treatment. Treatment is aimed at ...

Screening is highly recommended in all individuals with gigantism because half of the cases are due to a known hereditary genetic defect [5]. This ...