Kinetic solubility testing is typically conducted during the early stages of drug discovery, including lead identification and lead optimization, to guide the ...

Many drug discovery experiments are conducted under "kinetic" solubility conditions. In drug discovery, solubility has a major impact on bioassays, formulation ...

27 дек. 2023 г. · Kinetic aqueous or buffer solubility is important parameter measuring suitability of compounds for high throughput assays in early drug ...

Solubility is a crucial physicochemical property for drug candidates and is important in both drug discovery and development. Poor solubility is detrimental ...

The turbidimetric solubility assay is a discovery screening assay and calculates the kinetic solubility of a test compound by measuring its turbidimetry at ...

15 мая 2018 г. · Kinetic solubility offers a high-throughput method with relatively small amount of compound, especially useful in the early discovery phases.

The high throughput solubility methodologies in drug discovery are typically kinetic methods, in which solubility is determined using compound DMSO stock ...

A broader appreciation of aqueous solubility is changing how researchers pursue the drug discovery process from library design to screening to hit optimization.

16 февр. 2024 г. · Kinetic solubility is a critical parameter in the early stages of drug discovery. Starting from stock solutions, high-throughput kinetic ...

4 апр. 2024 г. · Kinetic solubility testing assesses the rate of dissolution over time. This is typically conducted during the early stages of drug discovery, ...