13 июл. 2021 г. · ... KIT gene mutation. More than 80 percent of individuals with systemic mastocytosis have a mutation in the KIT gene that replaces the protein ...

7 дней назад · Mutations in the KIT gene are associated with melanomas on chronic sun-damaged skin, acral and mucosal sites, and in older patients. KIT ...

The efficacy of imatinib (trade name Gleevec), a KIT inhibitor, is determined by the mutation status of KIT: When the mutation has occurred in exon 11 (as ... Cell surface marker · Role in cancer · Interactions

13 июл. 2021 г. · Mutations in the KIT gene are the most common genetic changes associated with gastrointestinal stromal tumors (GISTs). GISTs are a type of tumor ...

KIT Mutation is an inclusion criterion in 13 clinical trials for malignant solid tumor, of which 11 are open and 2 are closed. Of the trials that contain ...

27 февр. 2024 г. · In this review, we elucidate the biologic mechanism of KIT variants and update the underlying mechanism of the expression of KIT gene, which are exclusively ...

Mutations of c-KIT causing spontaneous activation of the KIT receptor kinase are associated with sporadic adult human mastocytosis (SAHM) and with human ...

27 сент. 2023 г. · The c-KIT activation mutation is the most common mutation detected in the GIST, accounting for 75–80% of cases, followed by the platelet-derived ...

Dasatinib, imatinib, sorafenib, and sunitinib have evidence of efficacy in patients with KIT mutation in thymic carcinoma [4]. Acute Myeloid Leukemia +. KIT is ...

Approximately 60-80% of GISTs harbor mutations in KIT. The majority of these mutations occur in exon 11 (70-90%) but mutation can also be seen in exons 9, 13, ...