21 июн. 2021 г. · LEF1 is a transcription factor for B and T cells and is involved in the Wnt / CTNNB1 pathway which regulates normal development of airway submucosal glands.

LEF1 is a useful marker in the differential diagnosis of CLL in difficult cases. It shows a high specificity (92%) and a reasonable sensitivity (70%) for ...

24 апр. 2024 г. · LEF1 negative, usually CD5 negative. Prolymphocytic B cell leukemia: Variable immunophenotype, bright CD20 and sIg; > 55% of lymphoid cells are ...

24 янв. 2023 г. · Pathophysiology. Subset of these lesions has inactivating mutations in LEF1 affecting the Wnt / β catenin pathway, which is important in ...

12 авг. 2022 г. · LEF1. Can be positive in 4 - 9% of mantle cell lymphomas (Ann Diagn Pathol 2017;26:57). Flow cytometry description. CD5+, CD19+, CD20+, CD22+ ...

15 нояб. 2023 г. · Marginal zone lymphoma, MALT type is an extranodal, low grade B cell lymphoma composed by a heterogeneous population of centrocyte-like, ...

21 сент. 2023 г. · WNT activated deep penetrating / plexiform melanocytoma (nevus) is a cellular melanocytic nevus with extension into deep dermis or subcutis ...

Lymphoma, EBV related lymphoid proliferations, flow cytometry, molecular overview (pending), staging-primary cutaneous, WHO 2019, GI hematolymphoid tumors. Classic Hodgkin lymphoma · Follicular-usual · Dlbcl, nos · CLL / SLL

To investigate lymphoid enhancer factor 1 (LEF-1) protein expression in medulloblastomas (MBs) and its correlation with molecular grouping of MBs.

Useful for suggests clinical disorders or settings where the test may be helpful differentiating cancers of B-cell origin.