21 июл. 2021 г. · Both of M1 and M2 macrophages are involved in the affection of tumor-related inflammatory [6], whereas M2 is prone to promote angiogenesis and ...

Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) are composed ... Abstract · Introduction · Cancer Immunotherapy and...

The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, ...

6 окт. 2020 г. · In conclusion, transcriptomically defined “M1” or “M1”/“M2” high tumors were associated with aggressive cancer biology and favorable tumor ...

3 дек. 2020 г. · Both M1 and M2 macrophages have high degree of plasticity and thus can be converted into each other upon tumor microenvironment changes or ...

In contrast to M1-TAMs, M2 macrophages promote tumor progression and are correlated to poor prognosis in various cancers. Therefore, uncovering the ...

10 февр. 2024 г. · Furthermore, genes linked to M1-like and M2-like TAM profiles are expressed simultaneously in almost all types of cancer macrophage subgroups.

M1 macrophages are involved in immune activation, promoting apoptosis and phagocytosis of cancer cells. M2 macrophages were mainly activated by IL-4 and mainly ...

22 мар. 2022 г. · M2 macrophages are generally recognized to have a protumor role, while the effect of M1 macrophages in cancer is controversial.