10 окт. 2010 г. · Here we directly visualize myosin V molecules walking along actin tracks, using high-speed atomic force microscopy.

This microscopy clearly visualized myosin V molecules walking on actin filaments and at last provided irrefutable evidence for the swinging lever-arm motion ...

MyoV is an ideal molecule to dissect the molecular basis for processivity. It expresses well in in vitro systems, so mutants can be prepared and studied.

18 июн. 2014 г. · This microscopy clearly visualized myosin V molecules walking on actin filaments and at last provided irrefutable evidence for the swinging ...

Walking with myosin V · The key to processivity lies in the kinetics · Kinetic gating increases the run length · MyoV moves via a hand-over-hand mechanism where ...

The new results indicate that myosin-Va tilts its light chain binding domains to 'walk' along actin in a hand-over-hand fashion.

This study attempts to understand the directionality in myosin V, one of the actin-based cytoskeleton motors involved in shuttling cellular cargo.

22 окт. 2024 г. · The dynamic behaviour of myosin V molecules translocating along actin filaments has been mainly studied by optical microscopy.

4 июл. 2018 г. · Here, we describe methods to image myosin V molecules walking on actin filaments with high-speed atomic force microscopy.

25 мая 2007 г. · Walking (toward left) on an actin filament (magenta) begins with binding of ATP to the trailing head to dissociate it from actin. The leading ...