There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be defined as an abnormal hemostatic response secondary to trauma.

31 янв. 2017 г. · The pathophysiology of trauma-induced coagulopathy consists of coagulation activation, hyperfibrino(geno)lysis, and consumption coagulopathy.

Tissue injury triggers an adaptive response, characterized by increased thrombin generation, fibrinolysis shutdown, and platelet activation with the release of ...

28 февр. 2024 г. · Endogenous TIC is driven by the combination of hypovolemic shock and substantial tissue injury, resulting in endothelial damage, glycocalyx ...

29 апр. 2021 г. · Tissue damage with endothelial disruption activates the coagulation system at the injury site via TF, a transmembrane protein expressed within ...

4 авг. 2022 г. · TIC originates from severe tissue damage combined with haemorrhagic shock [3], resulting in an inability to form and maintain clots leading to ...

1 июн. 2022 г. · Trauma-induced coagulopathy (TIC) is an alteration in the body's coagulation capacity that is attributable to injury and manifests in a spectrum ...

1 дек. 2017 г. · Acute Traumatic Coagulopathy occurs immediately after massive trauma when shock, hypoperfusion, and vascular damage are present.

24 мар. 2021 г. · Trauma activates the neurohumoral system, leading to increased secretion of inflammatory cytokines and hormones, such as adrenaline and ...

20 янв. 2017 г. · The first phase is immediate activation of multiple hemostatic pathways, with increased fibrinolysis, in association with tissue injury and/or ...