The well-known pathogenesis of RA includes production of autoantibodies, mediation of immune cells, activation of inflammatory pathways, and proliferation of synovium .
10 мар. 2024 г.
The pathology of RA is characterized by the infiltration of several inflammatory cells into both the pannus and the joint fluid and by subsequent tissue ... |
Rheumatoid arthritis is a synovial inflammatory disease marked by joint infiltration by immune cells and damage to the extracellular matrix. |
30 июн. 2023 г. · The pathogenesis of rheumatoid arthritis (RA) is complex, with multiple genetic, environmental, immunologic, and other factors contributing to ... |
The RA pathogenesis typically occurs in synovial joints, where immune cells invade the synovium. In addition, the number of FLS in the underlying layer of the ... |
13 дек. 2022 г. · Here, we review recently described immunologic mechanisms that drive breach of tolerance, chronic synovitis, and remission. |
In RA, the hypertrophied synovium (also called pannus) invades and erodes contiguous cartilage and bone. As such, it can be thought of as a tumor-like tissue, ... |
5 сент. 2023 г. · RA is theorized to develop when a genetically susceptible individual (eg, a carrier of HLA-DR4 or HLA-DR1 ) experiences an external factor (eg, ... Presentation · Treatment · Workup |
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