It is an incompletely understood process that consists of a spectrum ranging from excessive breakdown (hyperfibrinolysis) and the shutdown of fibrinolysis.

The duration of fibrinolysis shutdown after postinjury resuscitation may be the critical insult leading to organ injury and thrombotic complications. Acute ...

16 сент. 2017 г. · This review presents the current evidence on the pathophysiology, diagnostic challenges, as well as the management of this hemostatic dysfunction.

trauma patients with normal fibrinolysis had better outcomes—the extent and severity of trauma determines the release of tissue-type plasminogen activator from ...

FA occurs in the majority of trauma patients, and the magnitude of FA correlates with poor clinical outcome.

There were high levels of fibrinolytic activity (D-dimer) throughout. This pattern was present in patients across a broad range of injury severities.

In conclusion, this study demonstrates that both delayed-onset and persistent ROTEM hypofibrinolysis are associated with organ dysfunction and late mortality ...

16 апр. 2015 г. · Following TBI, there is an increase in brain-derived tPA- and uPA-mediated fibrinolysis that promotes ICH. TXA blocks tPA-mediated fibrinolysis ...

31 янв. 2017 г. · The pathophysiology of trauma-induced coagulopathy consists of coagulation activation, hyperfibrino(geno)lysis, and consumption coagulopathy.

Primary hyperfibrinolysis is a rapid and intense hyperfibrinolytic state that occurs in a subset of trauma patients and if not detected early can result in ...