Of the three subtypes of IDH, IDH1 mainly exists in peroxisome and cytoplasm, and IDH2 and IDH3 are located in the mitochondria [88].

Specific mutations in the isocitrate dehydrogenase gene IDH1 have been found in several tumor types, notably brain tumors including astrocytoma and ...

3 нояб. 2024 г. · The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and ...

IDH3 is also located in the mitochondria and catalyzes the irreversible conversion of isocitrate to α-ketoglutarate and NAD+ to NADH. IDH2 has been shown to ...

1 февр. 2016 г. · This enzyme is primarily found in the fluid-filled space inside cells (the cytoplasm). It is also found in cellular structures called ...

Isocitrate dehydrogenase (IDH) is an enzyme present in the cytosol (IDH1) and mitochondria (IDH2 and IDH3). In the mitochondrion, it catalyzes the irreversible ...

20 мая 2012 г. · Isocitrate dehydrogenase 2 (IDH2) is located in the mitochondrial matrix. IDH2 acts in the forward Krebs cycle as an NADP+-consuming enzyme, ...

The isocitrate dehydrogenase (IDH) proteins are ... IDH1 is found in the cytoplasm and peroxisomes, whereas IDH2 and IDH3 are found in the mitochondria.

A gene that makes a protein that is found inside small structures in cells called mitochondria and that helps the mitochondria make energy for many cell ...