23 дек. 2022 г. · YAP/TAZ activity in cancer cells promotes immunosuppression through the recruitment of MDSCs and TAMs. Immunosuppression is further promoted by ...

YAP/TAZ activity in cancer cells promotes immunosuppression through the recruitment of Myeloid-Derived Suppressor Cells (MDSCs) and Tumor-Associated Macrophages ...

YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cells attributes, proliferation, ...

12 июн. 2023 г. · Generally, YAP and TAZ activation or overexpression is not independently sufficient to spontaneously initiate cancer and, thus, they are not ...

22 мая 2023 г. · YAP/TAZ overexpression or activation is sufficient to induce tumor initiation and progression, as well as recurrence and therapeutic resistance.

12 июн. 2024 г. · YAP and TAZ are frequently activated in cancer and are the transcriptional effectors of the Hippo pathway, a highly conserved kinase cascade ...

In this review, we delineate the signaling nexus of YAP/TAZ axis, and present natural compounds as an alternate strategy to target cancer.

3 сент. 2018 г. · YAP/TAZ function as key nodes of multiple signaling pathways and play multiple regulatory roles in cancer cells. However, their roles in cancer ...

YAP/TAZ activity plays a prominent role in early liver development, with multiple studies in zebrafish and mouse showing that repression of the Hippo kinase ... Abstract · Introduction · Hippo pathway dysregulation...

Over the past decades, emerging evidence has underscored the roles of YAP/TAZ in promoting human cancers, including liver, lung, breast, brain, pancreas, and ...