29 янв. 2020 г. · YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm and the nucleus in response to multiple ...

31 дек. 2021 г. · Abnormal nuclear expression of YAP/TAZ proteins is associated with poor prognosis of different types of cancer [11,12,13,14,15]. In addition, ...

29 янв. 2020 г. · YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm and the nucleus in response to multiple ...

9 авг. 2023 г. · YAP/TAZ influences the expressions of downstream genes and proteins as well as enzyme activity in metabolic cycles, cell proliferation, ...

12 июн. 2024 г. · YAP and TAZ are frequently activated in cancer and are the transcriptional effectors of the Hippo pathway, a highly conserved kinase cascade ...

YAP and TAZ are transcriptional coactivators, do not have DNA binding capacity. So, active YAP/TAZ translocate to nucleus and interact majorly with TEA domain ...

Highlights · YAP and TAZ are transcription coactivators that display both common and specific features that support not completely overlapping cell functions.

Although YAP and TAZ are thought to be largely redundant and similarly regulated by Hippo signaling, they have developmental, structural, and physiological ...

YAP and TAZ activity is key for the growth of whole organs, for amplification of tissue-specific progenitor cells during tissue renewal and regeneration, and ...

YAP/TAZ is the key target to mediate breast cancer metastasis. YAP/TAZ mediates metastasis through cytoskeleton maintenance, vascular adhesion, EMT, cell ...